Vertebrate actin-related protein; 42 kD with 54% sequence homology with muscle actin and 69% similarity with cytoplasmic actin - more similar to conventional actin than to act-2; generally the core structure of the protein is conserved and differences are in surface loops. Forms part of the dynactin complex, an activator of dynein-driven vesicle movement.

Dictionary of molecular biology. 2004.

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  • dynactin — Dynein activator complex that stimulates vesicle transport. Includes dynactin (160 kD) and polypeptides of 62, 50, 45, 37, and 32, the 45 kD (possibly actin RPV) being the most abundant. All the subunits co sediment with antibody to dynactin 160… …   Dictionary of molecular biology

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